Current OSPREA Studies

We run a range of studies  that women can participate in – from women who are not currently pregnant, to those in the first trimester of pregnancy and onward. We can also refer you to other local research departments who are running pregnancy related studies if you are not suitable for any studies run by OSPREA.

Please take a look at the summary of some of our studies below.

If you are interested in taking part in any of the studies, you can use our main contact form, or contact the Research Midwives using details provided at the end of each study summary.

 

Pre-pregnancy Studies

OxWATCH
Learning more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy.
This study aims to learn more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy. The study is looking for women between 18-40 years old who are not currently pregnant, and have not had a baby before. Recruitment for this study is currently focusing on women who are planning a pregnancy in the near future. This study has its own section of this website - please click the link below If you are interested in the OxWatch study, please call (01865) 572259, email oxwatch@phc.ox.ac.uk or use the OxWatch contact form
Patient information leafletOxWATCH pagesOxWATCH Contact Form
PREDICTING RESPONSE TO SURGERY FOR ENDOMETRIOSIS PAIN
To understand of brain structure and function in relation to pain
Endometriosis (the presence of endometrial-like tissue in sites outside the womb) is a common cause of pelvic pain. Many women with this condition have surgery (usually a laparoscopy), both to confirm the diagnosis and to remove some/all of the tissue. Unfortunately, not all women with endometriosis find that their pain improves after surgery. For some women this is probably because the endometriosis was not the cause of their pain, however, for other women we believe that their central nervous system has been altered by their experience of pain and thus they continue to feel pain despite the original cause having been removed. The purpose of this study is to investigate whether there are factors we can measure before surgery that will predict which women will respond to surgical treatment of their pain. The results from this study will also improve our understanding of the involvement of the brain in the perception of pain in women with endometriosis, which may help us identify new ways to treat the pain.
Patient informationPatient informationOxWATCH Contact Form

Pregnancy Studies

Interbio 21st
Studying the growth of babies
This study is investigating the effects of nutrition on fetal growth and development and other factors that influence a healthy pregnancy. It is currently looking for women who are under 14 weeks pregnant who meet one or more of the following criteria - A current smoker, having had a previous pregnancy with raised blood pressure/pre-eclampsia, having had a previous pregnancy with a small-for-gestational age baby, having a low ‘PAPP-A’ (Pregnancy Associated Plasma Protein-A) on combined screening, and/or having a family history of pre-eclampsia. If you are interested in taking part in this study please contact the Lead Interbio 21st Research Midwife – Fenella Roseman on the following telephone numbers or using the email link below. Fenella Roseman - Tel: 07837 846234 or (01865) 221107.For further information, please follow the website and information leaflet links below
Email Lead Interbio 21st Research Midwife – Fenella RosemanInterbio 21stFurther Patient Information Leaflet
4P- This study is now closed to new participants and is there for information purposes.
Finding new ways to identify women who are unwell during and after pregnancy
This study is researching the normal observations of women in pregnancy and the postnatal period, by regularly measuring pulse, blood pressure, respiratory rate and temperature. This is to provide an accurate ‘normal range’ for reference when women become unwell during and after pregnancy. The ‘4P’ study is currently recruiting women already involved in the Interbio 21st study, where they have their observations taken at every scan. After the birth of their baby they are then given equipment to take home to do their own observations daily for 2 weeks. Please click the link below for further information If you are interested in the study please contact Research Midwife Jude Kemp on 01865 221074 or use our main contact form
Patient Information LeafletMain OSPREA Contact Form
OxWATCH
Learning more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy.
This study aims to learn more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy. The study is looking for women between 18-40 years old who are not currently pregnant, and have not had a baby before. Recruitment for this study is currently focusing on women who are planning a pregnancy in the near future. This study has its own section of this website - please click the link below If you are interested in the OxWatch study, please call (01865) 572259, email oxwatch@phc.ox.ac.uk or use the OxWatch contact form
Patient information leafletOxWatch pagesOxWatch Contact Form
Treat GDM
Using new technology to improve the care of women with gestational diabetes
This study is looking for pregnant women with gestational diabetes to take part in this research. It involves using a smart phone app to enable clinicians to regularly review blood sugar readings in real time rather than the woman attending a hospital appointment every 2 weeks. To take part participants may either be in the group that uses the app or the group that has our normal clinic care without the “app”. If you would be interested in finding out more about this research study please ask a member of staff at your next diabetic clinic appointment for more information on the TREAT-GDM study or contact the diabetic specialist midwife Katy Bartlett on 01865 851039
Patient Information
MRC Studies Pre-eclampsia and the Placenta
Finding out more about the causes of pre-eclampsia and ways to predict it
This group of studies are aiming to find out more about what causes pre-eclampsia, and also how to predict the condition. This involves women giving samples who have preeclampsia, and women giving samples who are having more straightforward pregnancies. If you are interested in this study please contact the MRC Research Midwife – Linda Holden on our main OSPREA information line (01865) 221107, or use our contact form
Patient Information for women with pre-eclampsiaPatient Information for women without pre-eclampsiaMain OSPREA Contact Form
PRISM
Investigating the effectiveness of progesterone to reduce the risk of miscarriage
The purpose of this study is to find out whether progesterone, a natural pregnancy hormone, can help to reduce the risk of miscarriage for women with bleeding in early pregnancy (up to 12 weeks). At the moment we do not know if progesterone helps to reduce the risk of miscarriage or not, but previous small studies show that it may be helpful. Women must be between 16-39 years of age attending the Early Pregnancy Assessment Unit.
Patient informationMain OSPREA Contact Form
ALIFE2
Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia
ALIFE 2 is a multi-centre randomised, phase III clinical trial to compare Low Molecular Weight Heparin (LMWH) with standard pregnancy surveillance in women with inherited thrombophilia (a condition where the blood has an increased tendency to form clots) and a history of recurrent miscarriage. This trial aims to try and find out if anticoagulant (“blood thinning”) treatment reduces the risk of miscarriage in pregnant women who have inherited thrombophilia and who have had at least two miscarriages.
Patient InformationMain OSPREA Contact Form
IONA® Twin Study
The IONA ® test is a prenatal screening test for Down’s, Edwards’ and Patau’s syndromes.
The IONA® test is an advanced non-invasive prenatal screening test for Trisomy 21, 18 and 13, and is currently offered to women with singleton pregnancies. We are running a clinical trial in the Women’s Centre called the IONA® Twin Study, to gain more understanding of how the IONA® test performs in pregnant mothers that are expecting twins. Developing a test like the IONA® test will help us to identify chromosomal abnormality in twin pregnancies from maternal blood, potentially avoiding the need to perform invasive amniocentesis or chorionic villus testing in the future.
Patient InformationPosterMain OSPREA Contact Form
RaDaR
The National Registry of Rare Kidney Diseases (RaDaR)
The National Registry of Rare Kidney Diseases (RaDaR) is an initiative by UK kidney specialists (the Renal Association and the UK Renal Registry). It is designed to pull together information from patients who have certain rare kidney diseases. This will give a much better understanding of how these illnesses affect people. It will also speed up research. If the research discovers something helpful or leads to benefits, such as better diagnosis, treatments or general advice, your doctor will tell you. Taking part in RaDaR means that you agree that relevant information about your medical history can be held on a secure computer system operated by the UK Renal Registry. You will be given a secure password that will let you see your information via Patient View. You would also agree to receive information from RaDaR and the Rare Disease Group from time to time.
Patient informationInformation on rare kidneys diseasesMain OSPREA Contact Form

Birth

GOT-IT
Investigating a treatment for retained placenta after birth
A retained placenta (RP) is a complication after a normal birth, which affects nearly 11,000 woman in the UK each year. This is where the placenta is not delivered spontaneously after giving birth. It is a major cause of postpartum haemorrhage (major loss of blood) which can lead to severe health complications for the mother. The study will try to prove the clinical and cost effectiveness of a known treatment for angina, Glyceryl trinitrate (GTN) used to treat RP. We will compare GTN against a placebo (dummy treatment) in a randomised controlled blinded trial.
Patient informationMain OSPREA Contact Form
ANODE
Prophylactic antibiotics for the prevention of infection following operative delivery
The ANODE trial aims to findout if giving a single dose of antibiotics to mothers who have had a forceps or ventouse birth results in lower rates of infection. This is an important question to answer as there are concerns about over prescribing antibiotics but we know that infections can have serious consequences and make life very difficult for new mums. You may be invited to take part in ANODE if, during your labour, the team caring for you recommend that they use forceps or ventouse to help deliver your baby.
Patient InformationMain OSPREA Contact Form

Postnatal Studies

Interbio 21st
Studying the growth of babies
This study is investigating the effects of nutrition on fetal growth and development and other factors that influence a healthy pregnancy. It is currently looking for women who are under 14 weeks pregnant who meet one or more of the following criteria - A current smoker, having had a previous pregnancy with raised blood pressure/pre-eclampsia, having had a previous pregnancy with a small-for-gestational age baby, having a low ‘PAPP-A’ (Pregnancy Associated Plasma Protein-A) on combined screening, and/or having a family history of pre-eclampsia. If you are interested in taking part in this study please contact the Lead Interbio 21st Research Midwife – Fenella Roseman on the following telephone numbers or using the email link below. Fenella Roseman - Tel: 07837 846234 or (01865) 221107.For further information, please follow the website and information leaflet links below
Email Lead Interbio 21st Research Midwife – Fenella RosemanInterbio 21stFurther Patient Information Leaflet
4P- This study is now closed to new participants and is there for information purposes.
Finding new ways to identify women who are unwell during and after pregnancy
This study is researching the normal observations of women in pregnancy and the postnatal period, by regularly measuring pulse, blood pressure, respiratory rate and temperature. This is to provide an accurate ‘normal range’ for reference when women become unwell during and after pregnancy. The ‘4P’ study is currently recruiting women already involved in the Interbio 21st study, where they have their observations taken at every scan. After the birth of their baby they are then given equipment to take home to do their own observations daily for 2 weeks. Please click the link below for further information If you are interested in the study please contact Research Midwife Jude Kemp on 01865 221074 or use our main contact form
Patient Information LeafletMain OSPREA Contact Form
OxWATCH
Learning more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy.
This study aims to learn more about women of childbearing age, to find out more about their health and lifestyle and to see how health in later life is influenced by getting older, by their lifestyle or potentially pregnancy. The study is looking for women between 18-40 years old who are not currently pregnant, and have not had a baby before. Recruitment for this study is currently focusing on women who are planning a pregnancy in the near future. This study has its own section of this website - please click the link below If you are interested in the OxWatch study, please call (01865) 572259, email oxwatch@phc.ox.ac.uk or use the OxWatch contact form
Patient information leafletOxWatch pagesOxWatch Contact Form
Music, Motherhood and Mental Health
Understanding the role of creative activities in mental wellbeing
This study aims to understand the psychological wellbeing of pregnant women and new mothers, as well as their involvement in creative activities. The survey is part of a larger study investigating the impact of creative interventions on the symptoms of postnatal depression, and results will be used as the basis for research publications as well as to inform the provision of advice and support on mental wellbeing for new mothers.
Patient InformationPatient informationMain OSPREA Contact Form

 

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